Recent Publications

Probing DNA Structure and DNA/Ligand, DNA/Protein Contacts

T. Lan and L.W. McLaughlin (2001) “The Energetic Contribution of a Bifurcated Hydrogen Bond to the Binding of DAPI to dA-dT Rich Sequences of DNA.” J. Am. Chem. Soc. 123, 2064-2065.

T. Lan and L.W. McLaughlin (2000) “Minor Groove Hydration is Critical to the Stability of DNA Duplexes,” J. Am. Chem. Soc. 122, 6512-6513.

T. Searls, D.- L. Chen, T. Lan, and L.W. McLaughlin (2000) “Nucleoside Analogue Substitutions in the Trinucleotide DNA Template Recognition Sequence 3’-(CTG)-5’ and Their Effects on the Activity of Bacteriophage T7 Primase,” Biochemistry 39, 4375-4382.

T. Lan and L.W. McLaughlin (2001) “Minor Groove Functional Groups are Critical for the B-Form Conformation of Duplex DNA,” Biochemistry 40, 968-976.

Z. Sun, D. Chen, T. Lan and L.W. McLaughlin (2002) “Importance of Minor Groove Functional Groups for the Stability of DNA duplexes,” Biopolymers 65, 211-217.

K. Woods, T. Lan, L.W. McLaughlin and L.D. Williams (2003) “The Role of Minor Groove Functional Groups in DNA Hydration,” Nucleic Acids Res. 31, 1536-1540.

Meena; Sun, Zhenhua; Mulligan, Christine; McLaughlin, Larry W. (2006) “Removal of a Single Minor-Groove Functional Group Eliminates A-Tract Curvature,” J. Am. Chem. Soc. , 128(36), 11756-11757.

Sun, Zhenhua; McLaughlin, Larry W., Minor Groove Nucleobase Functional Groups Impact the Stability of Duplex DNA (2007) Biopolymers 87, 183-195

Sun, Zhenhua; McLaughlin, Larry W., (2007) “Probing the Nature of Three-Centered Hydrogen Bonds in Ligand-DNA Interactions in the Minor Groove,” J. Am. Chem. Soc129, 12531-12536.

Arico, J.W., Calhoun, A.K., Salandria, K.J., and McLaughlin, L.W., (2010) “Tetramethylsuccinimide as a Directing/Protecting Group in Purine Glycosylations,” Org. Lett., 12 (1), 120–122

Arico, J.W., Calhoun, A.K., and McLaughlin, L.W., (2010) “Preparation of the 2′-Deoxynucleosides of 2,6-Diaminopurine and Isoguanine by Direct Glycosylation,” J. Org. Chem. (Featured Article), 75 (5), 1360–1365

Salandria, K.J., Arico, J.W., Calhoun, A.K., and Mclaughlin, L.W., (2011) “Stability of DNA Containing a Structural Water Mimic in an A-T Rich Sequence,” J. Am. Chem. Soc., 133 (6), 1766–1768

Modified Nucleosides to Probe DNA Triplexes and DNA Polymerase Activity

S. Bevers, S. Schutte and L.W. McLaughlin (2000) “Perylene and Naphthalene Linkers for Stabilization of Triplexes Containing DNA and RNA Targets.” J. Am. Chem. Soc. 122, 5905-5915.

D.-L. Chen and L.W. McLaughlin (2000) “Use of pKa Differences To Enhance the Formation of Base Triplets Involving C-G and G-C Base Pairs.” J. Org. Chem. 65, 7468-7474.

Fraley , D. Chen and L.W. McLaughlin (2003) “An HIV Selective Nucleoside Chain Terminator,” J. Am. Chem. Soc. 125, 616-617.

Sun, Zhenhua; Lo, Wayne; McLaughlin, Larry W. 6-Amino-3-(b-D-2-deoxy-erythro-furanosyl)-2-fluoropyridine: a nucleoside analogue. Acta Crystallographica, Section E: Structure Reports Online (2006), E62(4), o1437-o1439.

Targeting Double-Stranded DNA Using the Janus-Wedge Format

D. Chen, Meena, S.K. Sharma and L.W. McLaughlin (2003) “Formation and Stability of a Janus-Wedge Type of DNA Triplex,” J. Am. Chem. Soc. 126, 70-71.

H. Chen, Meena, L.W. McLaughlin (2008) “A Janus-Wedge DNA Triplex with A-W1-T and G-W2-C Base Triplets,” J. Am. Chem. Soc. 130, 13190–13191

Nanoscale DNA Lattices

K.M. Stewart J. Rojo and L.W. McLaughlin (2003) “Synthesis of Multi-Arm Ru(II)-DNA Complexes for the Construction of Mesoscale Lattice-like Assemblies” J.C.S. Chem. Comm. 2934-2935.

K.M. Stewart and L.W. McLaughlin (2004) “Four-Arm Oligonucleotide Ni(II)-Cyclam Centered Complexes as Precursors for the Generation of Supramolecular Periodic Assemblies” J. Am. Chem. Soc. 126, 2050-2057.

K.M. Stewart, J. Rojo and L.W. McLaughlin (2004) “Ru(II) Tris(bipyridyl) Complexes with Six Oligonucleotide Arms as Precursors for the Generation of Supramolecular Assemblies,” Angew. Chem. Int. Ed. 43, 5808-5811.

Alternative Carbohydrate Backbones for Information Storage Polymers

A. Horhota, K. Zou, J.K. Ichida, B. Yu, L.W. McLaughlin, J.W. Szostak and J.C. Chaput (2005) “Kinetic Analysis of an Efficient DNA-dependent TNA Polymerase,” J. Am. Chem. Soc. 127, 7427-7434.

K. Zou, A. Horhota, B. Yu, J. Chaput, J.W. Szostak and L.W. McLaughlin (2005) “Synthesis of α-L-Threofuranosyl Nucleoside Triphosphates (tNTPs)” Org. Lett. 7, 1485-1487.

J.K. Ichida, A. Horhota, K. Zou, L.W. McLaughlin & J.W. Szostak (2005). High Fidelity TNA Synthesis by Therminator Polymerase. Nucl. Acids Res. 33, 5219-5225.

Z. Sun and L.W. McLaughlin (2006) ” Syntheses of Pyridine C-Nucleosides as Analogues of the Natural Nucleosides dC and dU,” J. Org. Chem. 71, 2922-2925.

Horhota, Allen T.; Szostak, Jack W.; McLaughlin, Larry W. Glycerol Nucleoside Triphosphates: Synthesis and Polymerase Substrate Activities. Organic Letters (2006), 8(23), 5345-5347.

Meena; Sam, Mui; Chen, Jesse; Pierce, Kathryn; Szostak, Jack; McLaughlin, Larry W. 2′,3′-Dideoxy-3′-Thionucleoside Triphosphates: Synthesis and Polymerase Substrate Activities (2007) Organic Letters 9, 1161-1165.