2024
127. Hill CJ, Datta S, McCurtin NP, Kimball HZ, Kingsley MC, Bayer AL, Martin AC, Peng Q, Weerapana E, Scheck RA*. A Modular Turn-On Strategy to Profile E2-Specific Ubiquitination Events in Living Cells. Angew Chem Int Ed Engl. 2024 Mar 22;63(13):e202319579.
126. Peng Q, Weerapana E*. Profiling nuclear cysteine ligandability and effects on nuclear localization using proximity labeling-coupled chemoproteomics. Cell Chem Biol. 2024 Mar 21;31(3):550-564.e9.
125. Loynd C, Singha Roy SJ, Ovalle VJ, Canarelli SE, Mondal A, Jewel D, Ficaretta ED, Weerapana E, Chatterjee A*. Electrochemical labelling of hydroxyindoles with chemoselectivity for site-specific protein bioconjugation. Nat Chem. 2024 Mar;16(3):389-397.
124. Falco JA, Wynia-Smith SL, McCoy J, Smith BC, Weerapana E*. Identification of Protein Targets of S-Nitroso-Coenzyme A-Mediated S-Nitrosation Using Chemoproteomics. ACS Chem Biol. 2024 Jan 19;19(1):193-207.
2023
123. Chan AN, Chen X, Falco JA, Bak DW, Weerapana E*, Li B*. Chemoproteomics Reveals Disruption of Metal Homeostasis and Metalloproteins by the Antibiotic Holomycin. ACS Chem Biol., 2023, 18, 1909-1914.
122. Liu C, Liu X, Zhou M, Xia C, Lyu Y, Peng Q, Soni C, Zhou Z, Su Q, Wu Y, Weerapana E, Gao J, Chatterjee A, Lin C, Niu J*. Fluorosulfate as a Latent Sulfate in Peptides and Proteins. J Am Chem Soc., 2023, 145, 20189-20195.
121. Kisty EA, Saart EC, Weerapana E*. Identifying Redox-Sensitive Cysteine Residues in Mitochondria. Antioxidants, 2023, 12, 992.
120. Singha Roy SJ, Loynd C, Jewel D, Canarelli SE, Ficaretta ED, Pham QA, Weerapana E, Chatterjee A*. Photoredox-Catalyzed Labeling of Hydroxyindoles with Chemoselectivity (PhotoCLIC) for Site-Specific Protein Bioconjugation. Angew Chem Int Ed Engl. 2023, 62, e202300961.
119. Kisty EA, Falco JA, Weerapana E*. Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells. Cell Chem Biol., 2023, 30, 321-336.e6.
118. Bak DW, Weerapana E*. Monitoring iron-sulfur cluster occupancy across the E. coli proteome using chemoproteomics. Nat Chem Biol. 2023,19, 356-366.
2022
117. Benns HJ, Storch M, Falco JA, Fisher FR, Tamaki F, Alves E, Wincott CJ, Milne R, Wiedemar N, Craven G, Baragaña B, Wyllie S, Baum J, Baldwin GS, Weerapana E, Tate EW, Child MA*. CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery. Nat Microbiol. 2022, 7, 1891-1905.
116. Maurais A, Weerapana E*. A peptide-crosslinking approach identifies HSPA8 and PFKL as selective interactors of an actin-derived peptide containing reduced and oxidized methionine. RSC Chem. Biol., 2022, 3, 1282-1289.
115. Perez M, Nance KD, Bak DW, Thalalla Gamage S, Najera SS, Conte AN, Linehan WM, Weerapana E, Meier JL*. Conditional Covalent Lethality Driven by Oncometabolite Accumulation. ACS Chem Biol. 2022, 17, 2789-2800.
114. Nasuhidehnavi A, Zhao Y, Punetha A, Hemphill A, Li H, Bechtel TJ, Rager T, Xiong B, Petrou VI, Gubbels MJ, Weerapana E, Yap GS*. A Role for Basigin in Toxoplasma gondii Infection. Infect Immun. 2022, 90, e0020522.
113. Engelberg K, Bechtel T, Michaud C, Weerapana E, Gubbels MJ*. Proteomic characterization of the Toxoplasma gondii cytokinesis machinery portrays an expanded hierarchy of its assembly and function. Nat Commun. 2022, 13, 464.
112. Canarelli SE, Swalm BM, Larson ET,* Morrison MJ,* Weerapana E*. Monitoring GAPDH activity and inhibition with cysteine-reactive chemical probes. RSC Chem Biol. 2022, 3, 972-982.
111. Kovalyova Y, Bak DW, Gordon EM, Fung C, Shuman JHB, Cover TL, Amieva MR, Weerapana E, Hatzios SK*. An infection-induced oxidation site regulates legumain processing and tumor growth. Nat Chem Biol. 2022, 18, 698-705.
110. Bak DW*, Weerapana E*. Chemoproteomic interrogation of selenocysteine by low-pH isoTOP-ABPP. Methods Enzymol. 2022, 662, 187-225.
109. Peeler JC*, Weerapana E*. Expression of selenoproteins via genetic code expansion in mammalian cells. Methods Enzymol. 2022, 662, 143-158.
2021
108. Maurais AJ, Salinger AJ, Tobin M, Shaffer SA, Weerapana E*, Thompson PR*. A Streamlined Data Analysis Pipeline for the Identification of Sites of Citrullination. Biochemistry, 2021, 60, 2902-2914.
107. Griffante G, Gugliesi F, Pasquero S, Dell’Oste V, Biolatti M, Salinger AJ, Mondal S, Thompson PR, Weerapana E, Lebbink RJ, Soppe JA, Stamminger T, Girault V, Pichlmair A, Oroszlán G, Coen DM, De Andrea M, Landolfo S. Human cytomegalovirus-induced host protein citrullination is crucial for viral replication. Nat Commun. 2021, 2, 3910.
106. Tagoe DNA, Drozda AA, Falco JA, Bechtel TJ, Weerapana E, Gubbels MJ. Ferlins and TgDOC2 in Toxoplasma Microneme, Rhoptry and Dense Granule Secretion. Life, 2021, 11, 217.
105. Isor A, Chartier BV, Abo M, Currens ER, Weerapana E, McCulla RD.* Identifying cysteine residues susceptible to oxidation by photoactivatable atomic oxygen precursors using a proteome-wide analysis. RSC Chem. Biol., 2021, 2, 577-591.
2020
103. Dey M, Weerapana E. Chemical Tools in Biological Discovery (Editorial). Cell Chem Biol., 2020, 27, 889-890.
102. Generation of Recombinant Mammalian Selenoproteins through Genetic Code Expansion with Photocaged Selenocysteine. Peeler JC, Falco JA, Kelemen RE, Abo M, Edinger LC, Chen J, Chatterjee A*, Weerapana E*. ACS Chemical Biology, 2020, 19, 1535-1540.
101. Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKα. Annand JR, Henderson AR, Cole KS, Maurais AJ, Becerra J, Liu Y, Weerapana E, Koehler AN, Mapp AK, Schindler CS*. ACS Med. Chem. Lett., 2020, 11, 1913-1918.
100. Keller LJ, Lentz CS, Chen YE, Metivier RJ, Weerapana E, Fischbach M, Bogyo M*. Characterization of serine hydrolases across clinical isolates of commensal skin bacteria Staphylococcus epidermidis using activity-based protein profiling. ACS Infect. Dis., 2020, 6, 930-938.
99. Italia JS, Peeler JC, Hillenbrand CM, Latour C, Weerapana E, Chatterjee A*. Genetically encoded protein sulfation in mammalian cells. Nat. Chem. Biol. 2020, 16, 379-382.
98. Salinger AJ, Dubuke ML, Carmona-Rivera C, Maurais AJ, Shaffer SA, Weerapana E, Thompson PR*, Kaplan MJ*. Technical comment on “Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis”. Sci. Immunol., 2020, 5, 5672.
97. Yoo E, Schulze CJ, Stokes BH, Onguka O, Yeo T, Mok S, Gnädig NF, Zhou Y, Kurita K, Foe IT, Terrell SM, Boucher MJ, Cieplak P, Kumpornsin K, Lee MCS, Linington RG, Long JZ, Uhlemann AC, Weerapana E, Fidock DA, Bogyo M*. The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites. Cell Chem Biol., 2020, 27, 143-157.
96. Bechtel TJ, Li C, Kisty EA, Maurais AJ, Weerapana E*. Profiling cysteine reactivity and oxidation in the endoplasmic reticulum. ACS Chem Biol., 2020, 15, 543-553.
2019
95. Sun B, Chang HH, Salinger A, Tomita B, Bawadekar M, Holmes CL, Shelef MA, Weerapana E, Thompson PR, Ho IC. Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination. JCI Insight. 2019, 4, 129687.
94. Peeler JC, Weerapana E*. Chemical Biology Approaches to Interrogate the Selenoproteome. Acc Chem. Res. 2019, 52, 2832-2840.
93. Engelberg K, Chen CT, Bechtel T, Sánchez Guzmán V, Drozda AA, Chavan S, Weerapana E, Gubbels MJ. The apical annuli of Toxoplasma gondii are composed of coiled-coil and signaling proteins embedded in the IMC sutures. Cell Microbiol., 2019, e13112.
92. Hoffman KS, Vargas-Rodriguez O, Bak DW, Mukai T, Woodward LK, Weerapana E, Söll D, Reynolds NM. A cysteinyl-tRNA synthetase variant confers resistance against selenite toxicity and decreases selenocysteine misincorporation. J Biol Chem., 2019, 294, 12855-12865.
91. Mondal S, Gong X, Zhang X, Salinger AJ, Zheng L, Sen S, Weerapana E, Zhang X, Thompson P. Halogen Bonding Increases the Potency and Isozyme-selectivity of Protein Arginine Deiminase 1 Inhibitors. Angew Chem Int Ed Engl., 2019, 58, 12476-12480.
90. Sorvillo N, Mizurini D, Coxon C, Martinod K, Tilvawala R, Cherpokova D, Salinger AJ, Seward RJ, Staudinger C, Weerapana E, Shapiro NI, Costello CE, Thompson P, Wagner DD. Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis after Vessel Injury. Circ Res. , 2019, 125, 507-519.
89. Zheng L, Nagar M, Maurais AJ, Slade DJ, Parelkar SS, Coonrod SA, Weerapana E, Thompson PR. Calcium Regulates the Nuclear Localization of Protein Arginine Deiminase 2. Biochemistry. , 2019, 58, 3042-3056.
88. Libiad M, Vitvitsky V, Bostelaar T, Bak DW, Lee HJ, Sakamoto N, Fearon ER, Lyssiotis CA, Weerapana E, Banerjee R. Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells. J Biol Chem., 2019, 294, 12077-12090.
87. Morimoto K, Cole KS, Kourelis J, Witt CH, Brown D, Krahn D, Stegmann M, Kaschani F, Kaiser M, Burton J, Mohammed S, Yamaguchi-Shinozaki K, Weerapana E, van der Hoorn RAL. Triazine probes targeting ascorbate peroxidases in plants. Plant Physiol., 2019, 180, 1848-1859.
86. Llabani E, Hicklin RW, Lee HY, Motika SE, Crawford LA, Weerapana E, Hergenrother PJ. Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis. Nat Chem. , 2019, 11, 521-532.
85. Bak DW, Weerapana E. Interrogation of Functional Mitochondrial Cysteine Residues by Quantitative Mass Spectrometry. Methods Mol Biol., 2019, 1967, 211-227.
84. Sen S, Mondal S, Zheng L, Salinger AJ, Fast W, Weerapana E, Thompson PR. Development of a Suicide Inhibition-Based Protein Labeling Strategy for Nicotinamide N-Methyltransferase. ACS Chem Biol., 2019, 14, 613-618.
3. Italia JS, Addy PS, Erickson SB, Peeler JC, Weerapana E, Chatterjee A. Mutually Orthogonal Nonsense-Suppression Systems and Conjugation Chemistries for Precise Protein Labeling at up to Three Distinct Sites. J Am Chem Soc., 2019, 141, 6204-6212.
82. Maurais AJ, Weerapana E. Reactive-cysteine profiling for drug discovery. Curr. Opin. Chem. Biol., 2019, 50, 29-36.
81. Kulkarni RA, Bak DW, Wei D, Bergholtz SE, Briney CA, Shrimp JH, Alpsoy A, Thorpe AL, Bavari AE, Crooks DR, Levy M, Florens L, Washburn MP, Frizzell N, Dykhuizen EC, Weerapana E, Linehan WM, Meier JL. A chemoproteomic portrait of the oncometabolite fumarate. Nat Chem Biol., 2019, 15, 391-400.
80. Long MJC, Lawson AP, Baggio R, Qian Y, Rozhansky L, Fasci D, El Oualid F, Weerapana E, Hedstrom L. Diarylcarbonates are a new class of deubiquitinating enzyme inhibitor. Bioorg Med Chem Lett., 2019, 29, 204-211.
79. Bak DW, Bechtel TJ, Falco JA, Weerapana E. Cysteine reactivity across the subcellular universe. Curr Opin Chem Biol., 2019, 48, 96-105.
2018
78. Gao J, Yang F, Che J, Han Y, Wang Y, Chen N, Bak DW, Lai S, Xie X, Weerapana E, Wang C. Selenium-encoded isotopic signature targeted profiling. ACS Cent Sci., 2018, 4, 960-970.
77. Luo W, Guo F, McMahon A, Couvertier S, Jin H, Diaz M, Fieldsend A, Weerapana E, Rosbash M. NonA and CPX link the circadian clockwork to locomotor activity in drosophila. Neuron, 2018, 99, 768-780.
76. Nemmara VV, Tilvawala R, Salinger AJ, Miller L, Nguyen SH, Weerapana E, Thompson PR. Citrullination inactivates nicotinamide-N-methyltransferase. ACS Chem. Biol., 2018, 13, 2663–2672.
75. Bak DW, Gao J, Wang C, Weerapana E. A quantitative chemoproteomic platform to monitor selenocysteine reactivity within a complex proteome. Cell Chem. Biol., 2018, 9, 1157-1167.
74. Lentz CS, Sheldon JR, Crawford LA, Cooper R, Garland M, Amieva MR, Weerapana E, Skaar EP, Bogyo M. Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP). Nat Chem Biol., 2018, 14, 609–617.
73. Tilvawala R, Nguyen SH, Maurais AJ, Nemmara VV, Nagar M, Salinger AJ, Nagpal S, Weerapana E, Thompson PR. The rheumatoid arthritis-associated citrullinome. Cell Chem Biol., 2018, 25, 691-704.
72. Cole KS, Grandjean JMD, Chen K, Witt CH, O’Day J, Shoulders MD, Wiseman RL, Weerapana E. Characterization of an A-site selective protein disulfide isomerase A1 inhibitor. Biochemistry., 2018, 57, 2035-2043.
71. Nemmara VJ, Subramanian V, Muth A, Mondal S, Salinger AJ, Maurais AJ, Tilvawala R, Weerapana E, Thompson PR. The development of benzimidazole-based clickable probes for the efficient labeling of cellular protein arginine deiminases (PADs). ACS Chem Biol., 2018, 13, 712-722.
70. Abo M, Li C, Weerapana E. Isotopically-labeled iodoacetamide-alkyne probes for quantitative cysteine-reactivity profiling. Mol Pharm., 2018, 15, 743-749.
2017
69. Gorelenkova Miller O, Cole KS, Emerson CC, Allimuthu D, Golczak M, Stewart PL, Weerapana E, Adams DJ, Mieyal JJ. Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor. PLoS One., 2017, 12(11):e0187991.
68. Abo M, Weerapana E. Chemical probes for redox signaling and oxidative stress. Antioxid Redox Signal., 2018, 30, 1369-1386.
67. Sun B, Dwivedi1 N, Bechtel TJ, Paulsen JL, Muth A, Bawadekar M, Li G, Thompson PR, Shelef MA, Schiffer CA, Weerapana E, Ho I-C. Citrullination of NF-?B p65 promotes its nuclear localization and TLR-induced expression of IL-1ß and TNFa. Science Immunology, 2017, 2(12) eaal3062.
66. Quinti L, Dayalan Naidu S, Träger U, Chen X, Kegel-Gleason K, Llères D, Connolly C, Chopra V, Low C, Moniot S, Sapp E, Tousley AR, Vodicka P, Van Kanegan MJ, Kaltenbach LS, Crawford LA, Fuszard M, Higgins M, Miller JRC, Farmer RE, Potluri V, Samajdar S, Meisel L, Zhang N, Snyder A, Stein R, Hersch SM, Ellerby LM, Weerapana E, Schwarzschild MA, Steegborn C, Leavitt BR, Degterev A, Tabrizi SJ, Lo DC, DiFiglia M, Thompson LM, Dinkova-Kostova AT, Kazantsev AG. KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington’s disease patients. Proc Natl Acad Sci U S A., 2017, 114(23):E4676-E4685.
65. Lawson AP, Bak DW, Shannon DA, Long MJC, Vijaykumar T, Yu R, El Oualid F, Weerapana E, Hedstrom L. Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry. Oncotarget, 2017, 8(31), 51296-51316.
64. Casas-Selves M, Zhang A, Dowling JE, Hallen S, Kawatkar A, Pace NJ, Denz C, Pontz T, Garahdaghi F, Cao Q, Sabirsh A, Thakur K, O’Connell N, Hu J, Cornella-Taracido I, Weerapana E, Zinda M, Goodnow RA. Target deconvolution efforts on Wnt pathway screen reveal dual modulation of oxidative phosphorylation and SERCA2. ChemMedChem, 2017, 12(12):917-924.
63. Child MA, Garland M, Foe I, Madzelan P, Treeck M, van der Linden WA, Oresic Bender K, Weerapana E, Wilson MA, Boothroyd JC, Reese ML, Bogyo M. Toxoplasma DJ-1 regulates organelle secretion by a direct interaction with calcium-dependent protein kinase 1. MBio., 2017, 8, e02189-16.
62. Bak D.W., Pizzagalli M.D., Weerapana E. Identifying functional cysteine residues in the mitochondria. ACS Chem. Biol., 2017, 12, 947-957.
61. Weerapana E. Redox regulation: Taking AKTion on HNEs (News and Views). Nat. Chem. Biol., 2017, 13, 244-245.
60. Bechtel T.J., Weerapana E. From structure to redox: the diverse functional roles of disulfides and implications in disease. (Review) Proteomics, 2017, 17(6). doi: 10.1002/pmic.201600391.
59. Abo M., Bak D.W., Weerapana E. Optimization of caged electrophiles for improved monitoring of cysteine reactivity in living cells. ChemBioChem, 2017, 18, 81-84.
58. Qian Y., Weerapana E. A quantitative mass-spectrometry platform to monitor changes in cysteine reactivity. Methods Mol. Biol., 2017, 1491, 11-22.
2016
57. Martell J., Seo Y., Bak D.W., Kingsley S.F., Tissenbaum H.A., Weerapana E. Global cysteine-reactivity profiling during impaired insulin/IGF-1 signaling in C. elegans identifies uncharacterized mediators of longevity. Cell Chem. Biol., 2016, 23, 955-966.
56. Zhou Y.#, Wynia-Smith S.L.#, Couvertier S.M.#, Kalous K.S., Marletta M.A.*, Smith B.C.*, Weerapana E.* Chemoproteomic strategy to quantitatively monitor transnitrosation uncovers functionally relevant S-nitrosation sites on Cathepsin D and HADH2. Cell Chem. Biol., 2016, 23, 727-737.
55. Samarasinghe K.T., Munkanatta Godage D.N., Zhou Y, Ndombera F.T., Weerapana E., Ahn Y.H. A clickable glutathione approach for identification of protein glutathionylation in response to glucose metabolism. Mol. BioSyst., 2016, 12, 2471-2480.
54. Jones L.H., Weerapana E. Protein Labelling (Editorial Overview). Mol. BioSyst., 2016, 12, 1725-27.
53. Louie S.M., Grossman E.A., Crawford L.A., Ding L., Camarda R., Huffman T.R., Miyamoto D.K., Goga A., Weerapana E., Nomura D.K. GSTP1 is a driver of triple-negative breast cancer cell metabolism and pathogenicity. Cell Chem. Biol., 2016, 23, 567-578.
52. Crawford L.A., Weerapana E. A tyrosine-reactive irreversible inhibitor for glutathione S-transferase Pi (GSTP1). Mol. Biosyst., 2016, 12, 1768-1771.
51. Sanman L.E., Qian Y., Eisele N.A., Ng T.M., van der Linden W.A., Monack D.M., Weerapana E., Bogyo M. Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death. Elife, 2016, e13663.
50. Hatzios S.K., Abel S., Martell J., Hubbard T., Sasabe J., Munera D., Clark L., Bachovchin D.A., Qadri F., Ryan E.T., Davis B.M., Weerapana E.*, Waldor M.K.* Chemoproteomic profiling of host and pathogen enzymes active in cholera. Nat. Chem. Biol., 2016, 12, 268-74.
49. Saghatelian A., Nomura D. K., Weerapana E. Omics: The maturation of chemical biology. (Editorial Overview) Curr Opin Chem Biol., 2016, 30, v-vi. Special issue on “Omics”.
48. Clancy K.W., Weerapana E., Thompson P.R. Detection and identification of protein citrullination in complex biological systems. (Review) Curr Opin Chem Biol., 2016, 30, 1-6. Special issue on “Omics”.
2015
47. Lawson A.P., Long M.J., Coffey R.T., Qian Y., Weerapana E., El Oualid F., Hedstrom L. Naturally occurring isothiocyanates exert anticancer effects by inhibiting deubiquitinating enzymes. Cancer Res., 2015, 75, 5130-42.
46. Lewallen D.M., Bicker K.L., Subramanian V., Clancy K.W., Slade D.J., Martell J., Dreyton C.J., Sokolove J., Weerapana E., Thompson P.R. A chemical proteomic platform to identify citrullinated proteins. ACS Chem Biol., 2015, 10, 2520-8.
45. Abo M., Weerapana E. A caged probe for global analysis of cysteine reactivity in living cells. J. Am. Chem. Soc., 2015, 137, 7087-90.
44. Wei Y., Stec B., Redfield A.G., Weerapana E., Roberts M.F. Phospholipid binding sites of PTEN: Exploring the mechanism of PIP2 activation. J. Biol. Chem., 2015, 290, 1592-606.
43. Bak D.W., Weerapana E. Cysteine-mediated redox signalling in the mitochondria. (Review) Molecular Biosystems, 2015, 11, 678-97.
42. Shannon D.A., Weerapana E. Covalent protein modification: the current landscape of residue-specific electrophiles. (Review) Current Opinion in Chemical Biology, 2015, 24, 18-26. Special issue on “Omics”.
2014
41. Couvertier S.M., Zhou Y., Weerapana E. Chemical-proteomic strategies to investigate cysteine posttranslational modifications. (Review) Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics, 2014, 1844, 2315-30.
40. Tamburini, F., Kelly T., Weerapana E.*, Byers J.* Paper to Plastics: An interdisciplinary summer outreach project in sustainability. J. Chem. Ed., 2014, 91, 1574-79.
39. Pace, N. J., Weerapana, E. Zinc-binding cysteines: diverse functions and structural motifs. (Review) Biomolecules, 2014, 4, 419-34. Special issue on “Metal-binding Proteins”.
38. Zhuang, J., Kuo, C.H., Chou, L.Y., Liu, D.Y., Weerapana, E.*, Tsung, C.K.* Optimized metal-organic-framework nanospheres for drug delivery: evaluation of small-molecule encapsulation. ACS Nano, 2014, 8, 2812-9.
37. Shannon, D.A., Banerjee, R., Webster, E.R., Bak, D.W., Wang, C., Weerapana, E. Investigating the proteome reactivity and selectivity of aryl halides J. Am. Chem. Soc., 2014, 136, 3330-3.
36. Martell, J., Weerapana, E. Applications of copper-catalyzed click chemistry in activity-based protein profiling. (Review) Molecules, 2014, 19, 1378-93. Special Issue on “Bioorthogonal Chemistry”
35. Couvertier, S. M., Weerapana, E. Cysteine-reactive chemical probes based on a modular 4-amino-piperidine scaffold. MedChemComm, 2014, 5, 358-62.
34. Pace, N.J., Weerapana, E. A competitive chemical-proteomic platform to identify zinc-binding cysteines. ACS Chemical Biology, 2014, 9, 651-6.
33. Shannon D.A., Weerapana, E. Orphan PTMs: Rare, yet functionally important modifications of cysteine. (Review) Biopolymers, 2014, 101, 156-64. Special issue on “The Next Frontier of Posttranslational Modifications
2013
32. Banerjee, R., Brown, D.R., Weerapana, E. Recent developments in the synthesis of bioactive 2,4,6-trisubstituted-1,3,5-triazines. (Review) Synlett, 2013, 24, 1599-1605.
31. Schwaid, A.G.#, Shannon, D.A.#, Ma, J., Slavoff, S.A., Levin, J.Z., Weerapana, E.*, Saghatelian, A.* Chemoproteomic discovery of cysteine-containing human short open reading frames. J. Am. Chem. Soc., 2013, 135, 16750-3.
30. Qian, Y., Martell, J., Pace N.J., Ballard, E.T., Johnson, D.S.*, Weerapana, E*. An isotopically tagged azobenzene-based cleavable linker for quantitative proteomics. ChemBioChem, 2013, 14, 1410-1414.
29. Banerjee, R., Pace, N.J., Brown, D.R., Weerapana, E. 1,3,5-Triazine as a modular scaffold for covalent inhibitors with streamlined target identification. J. Am. Chem. Soc., 2013, 135, 2497-500.
28. Child, M.A., Hall C.I., Beck, J.R., Ofori, L.O., Albrow,V.E., Garland, M., Bowyer, P.W., Bradley,P.J., Powers, J.C., Boothroyd, J.C., Weerapana, E., Bogyo, M. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. Nat. Chem. Biol., 2013, 9, 651-6.
27. Lee, B.C., Péterfi, Z., Hoffmann, F.W., Moore, R.E., Kaya, A., Avanesov, A., Tarrago, L., Zhou, Y., Weerapana, E., Fomenko, D.E., Hoffmann, P.R., Gladyshev, V.N. MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation. Molecular Cell, 2013, 51, 397-404.
26. Pace, N.J., Weerapana, E. Diverse functional roles of reactive cysteines. (Review) ACS Chemical Biology, 2013, 8, 283-96.
25. Gu C., Shannon D.A., Colby T., Wang Z., Shabab M., Kumari S., Villamor J.G., McLaughlin C.J., Weerapana E., Kaiser M., Cravatt B.F., van der Hoorn R.A.L. Chemical proteomics with sulfonyl fluoride probes reveals selective labeling of functional tyrosines in glutathione transferases. Chemistry & Biology, 2013, 20, 541-548.
2012
24. Shannon DA, Gu C, McLaughlin CJ, Kaiser M, van der Hoorn RA, Weerapana E*. Sulfonyl fluoride analogues as activity-based probes for serine proteases. ChemBioChem, 2012, 13, 2327-2330.
23. Pace NJ, Pimental DR, Weerapana E*. An inhibitor of glutathione S-transferase omega 1 that selectively targets apoptotic cells. Angew. Chem. Int. Ed. Engl. 2012, 51, 8365-8368.
22. Tarrago L, Kaya A, Weerapana E, Marino SM, Gladyshev VN*. Methionine sulfoxide reductases preferentially reduce unfolded oxidized proteins and protect cells from oxidative protein unfolding. J. Biol. Chem., 2012, 287, 24448-24459.
Prior to Boston College:
21. Wang, C., Weerapana, E., Blewett, M.M., Cravatt, B.F. A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles. Nature Methods, 2014, 11, 79-85.
20. Deng X., Weerapana E., Ulanovskaya O., Sun F., Liang H., Ji Q., Ye Y., Fu Y., Zhou L., Li J., Zhang H., Wang C., Alvarez S., Hicks L.M., Lan L., Wu M., Cravatt B.F., He C. Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria. Cell Host Microbe, 2013, 13, 358-70.
19. Ramya TN, Weerapana E, Cravatt BF, Paulson JC*. Glycoproteomics enabled by tagging sialic acid or galactose terminated glycans. Glycobiology, 2012, 23, 211-221.
18. Hall C, Reese M, Weerapana E, Child M, Bowyer P, Albrow V, Heraldsen J, MacDonald P, Sandoval ED, Ward G, Cravatt BF, Boothroyd J, Bogyo M*. A chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion and invasion. Proc. Natl. Acad. Sci. U.S.A., 2011, 108, 10568-10573.
17. Bachovchin DA, Zuhl AM, Speers AE, Wolfe MR, Weerapana E, Brown SJ, Rosen H, Cravatt BF*. Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1. J. Med. Chem., 2011, 54, 5229-5236.
16. Ahn K*, Smith SE, Liimatta MB, Beidler D, Sadagopan N, Dudley DT, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stiff C, Nomanbhoy TK, Weerapana E, Johnson DS, Cravatt BF*. Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective FAAH inhibitor that reduces inflammatory and noninflammatory pain. J. Pharmacol. Exp. Ther., 2011, 338, 114-124.
15. Weerapana E#, Wang C#, Simon GM, Richter F, Khare S, Dillon BDM, Bachovchin DA, Mowen K, Baker D, Cravatt BF. Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature, 2010, 468, 790-795. #These authors contributed equally to this work.
14. Johnson DS*, Weerapana E, Cravatt BF*. Strategies for discovering and derisking covalent, irreversible enzyme inhibitors. Fut. Med. Chem., 2010,2, 949-964.
13. Wurdak H, Zhu S, Aimone L, Lairson LL, Watson J, Chopiuk G, Min KH, Demas J, Charette B, Halder R, Weerapana E, Cravatt BF, Cline HT, Peters EC, Zhang J, Walker JR, Wu C, Zhang J, Tuntland T, Cho CY, Shultz PG*. A small molecule accelerates neuronal differentiation in the adult rat.Proc. Natl. Acad. Sci. U.S.A., 2010, 107, 16542-16547
12. Ramya TNC, Weerapana E, Liao L, Zeng Y, Tateno H, Liao L, Yates J, Cravatt BF, Paulson JC*. In situ trans ligands of CD22 identified by glycan-protein photocross-linking-enabled proteomics. Mol. Cell. Proteomics, 2010, 9, 1339-1351.
11. Ahn K*, Johnson DS, Mileni M, Beidler D, Long JZ, McKinney MK, Weerapana E, Sadagopan N, Liimatta M, Smith SE, Lazerwith S, Stiff C, Kamtekar S, Bhattacharya K, Zhang Y, Swaney S, Van Becelaere K, Stevens RC*, Cravatt BF*. Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem. Biol., 2009, 16, 411-420.
10. Weerapana E, Simon GM, Cravatt BF*. Disparate proteome reactivity profiles of carbon electrophiles. Nature Chem. Biol., 2008,4, 405-407.
9. Weerapana E, Speers AE, Cravatt BF*. Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP) – a general method for mapping sites of probe modification in proteomes. Nature Protocols, 2007, 2, 1414-1425.
8. Hanson SR, Hsu TL, Weerapana E, Kishikawa K, Simon GM, Cravatt BF*, Wong CH*. Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes. J. Am. Chem. Soc., 2007,129, 7266-7267.
7. Chen MC, Weerapana E, Ciepichal E, Stupak J, Reid CW, Swiezewska E, Imperiali B*. Polysisoprenyl specificity in the Campylobacter jejuni N-linked glycosylation pathway. Biochemistry, 2007, 46, 14342-14348.
6. Glover KJ#, Weerapana E#, Chen MM, Imperiali B*. Direct biochemical evidence for the utilization of UDP-bacillosamine by PglC, an essential glycosyl-1-phosphate transferase in the Campylobacter jejuni N-linked glycosylation pathway. Biochemistry, 2006,45,5343-5350. #These authors contributed equally to this work.
5. Weerapana E, Imperiali B*. Asparagine-linked protein glycosylation: From eukaryotic to prokaryotic systems. Glycobiology, 2006,16, 91R-101R.
4. Glover KJ#, Weerapana E#, Numao S, Imperiali B. Chemoenzymatic synthesis of glycopeptides with PglB, a bacterial oligosaccharyl transferase from Campylobacter jejuni. Chem. Biol., 2005,12, 1311-1315. #These authors contributed equally to this work.
3. Weerapana E, Glover KJ, Imperiali B*. Investigating bacterial N-linked glycosylation: synthesis and glycosyl acceptor activity of the undecaprenyl pyrophosphate-linked bacillosamine. J. Am. Chem. Soc., 2005,127, 13766-13767.
2. Glover KJ, Weerapana E, Imperiali B*. In vitro assembly of the undecaprenylpyrophosphate-linked heptasaccharide for prokaryotic N-linked glycosylation. Proc. Natl. Acad. Sci. U.S.A., 2005,102, 14255-14259.
1. Weerapana E, Imperiali B*. Peptides to peptidomimetics: towards the design and synthesis of bioavailable inhibitors of oligosaccharyl transferase. Org. Biomol. Chem., 2003, 1, 93-99.